Azlocillin is a Promising drug candidate for Lyme disease. Early results of this team’s screening process, first published in 2016, led to the discovery of another promising Lyme drug candidate, disulfiram, which is approved by the Food and Drug Administration for the treatment of alcohol abuse disorder. Azlocillin was previously approved by the FDA for the treatment of alcohol abuse disorder. A new study gives hope that an effective treatment for Lyme disease may be available in the future. Article reprinted with permission from Stanford’s Institute for Stem Cell Biology and Regenerative Medicine: https://scopeblog.stanford.edu/2020/03/30/lyme-disease-bacteria-eradicated-by-new-drug-in-early-tests/. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. As Pothineni said in the Stanford Medicine news release: “We have been screening potential drugs for six years … We’ve screened almost 8,000 chemical compounds. Drop Us A LineOr Contact Us Directly At:email@example.com. I responded to treatment. Frustrated by the lack of treatment options for Lyme disease patients with lingering symptoms, Rajadas and his team began hunting for a better alternative in 2011. Rajadas and Pothineni have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. We have tested 50 molecules in the dish. Azlocillin also appears to kill drug-tolerant persisters very effectively. “We have been screening potential drugs for six years,” Pothineni said. If the disease isn’t treated promptly, it can lead to life-threatening heart issues and chronic neurological problems. To help combat the complications of antibiotics in the treatment of Lyme disease, many people turn to probiotics. Along the way, I’ve met many people suffering with this horrible, lingering disease. It took ten doctors and a year to discover the root cause: We’d been bitten by unseen ticks harboring the parasites that cause Lyme disease and babesiosis, a malaria-like disease. Photo by Gabor Tinz/Shutterstock. It can affect various organs, including the brain, skin, heart, joints and nervous system, and cause heart problems and arthritis if untreated. Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. This image shows how the Lyme bacteria, Borrelia burgdorferi, form protective round body “persisters” when threatened by defensive immune system biochemicals in blood serum. “Super responders” are key to personalized Lyme disease treatment. Be part of a community that cares. Ask your questions here. It can affect various organs, including the brain, skin, heart, joints and nervous system, and cause heart problems and arthritis if untreated. This drug study, published online in Scientific Reports, was conducted by a team led by Jayakumar Rajadas, PhD, assistant professor of medicine and director of Stanford’s Biomaterials and Advanced Drug Delivery Laboratory, and research associate Venkata Raveendra Pothineni, PhD. Azlocillin appears to kill the morphed forms of the bacteria as well as the active. Patients Should Have a Say in How Their Doctors Treat Them. Editor’s note: Any medical information included is based on a personal experience. The team zeroed in on azlocillin as a promising drug candidate through the use of high throughput drug screening. Article reprinted with permission from Stanford’s Institute for Stem Cell Biology and Regenerative Medicine: Can Treating Mast Cells Help Neurological Lyme Disease? The new treatment involves the drugs cefotaxime and azlocillin. The existing treatment for Lyme disease is standard antibiotics, which kill the infection except for 20% of the population with the illness. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease Control and Prevention. Later, I discover that my situation wasn’t all that uncommon. Researchers tested azlocillin in mice infected with Lyme disease at 7-day, 14-day and 21-day intervals and found that it eliminated the infection. I n 2002, my husband and I became seriously ill after a vacation to Martha’s Vineyard. Putting Lyme Behind You: Basic Lyme for Patients, Family and Friends, Lyme Disease and MSIDS: Diagnosis and Treatment Protocols for the Chronically Ill Patient, Review of Lyme disease Diagnosis and Treatment, Using Integrative Medicine to Heal from Lyme Disease. The best drug candidates were retested in larger culture dishes, then the safest of these were tested in vivo in seven mice. Posted 10/7/2019 7:39 AM (GMT -7) Azlocillin sodium is another drug to watch as just like Disulfiram it completely sterilized Borrelia in vitro in that Stanford study. The existing treatment for Lyme disease is standard antibiotics, which kill the infection except for 20% of the population with the illness. Additionally, in lab dishes, the azlocillin killed drug-tolerant forms of B. burgdorferi , “indicating that it may work as a therapy for lingering symptoms of Lyme disease,” according to the Stanford team.